The best research fundamentally changes scientific thinking or medical practice. This may be by changing concepts of disease mechanisms or of normal physiology, by improving diagnostic methods, by altering conventional patient treatment etc.

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Such research is likely to be cited often. The frequency of citation is a reasonable, albeit imperfect, guide to scientific excellence.

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Here we display our citation classics, defined as articles quoted more than 100 times. These discoveries have "made a difference" and we briefly describe their impact. You will also see these citation classics showcased on screens around the Melbourne Brain Centre, where the Epilepsy Research Centre is based.